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Carolyn and I have appreciated the work of the late neuroscientist and pharmacologist Candace Pert, who conducted groundbreaking research that changed the way scientists view the relationship between mind and body, and was a major proponent of alternative medicine. Pert discovered the opiate receptor— the cellular binding site for endorphins in the brain— and she paved the way for the field of mind-body medicine.
Candace Beebe Pert was born in 1946 in New York City. Her father was a commercial artist and her mother worked in the courts as a clerk typist. Although Pert was initially interested in studying psychology, she studied biology in college and sought a more solid scientific basis for understanding human behavior. Pert completed her undergraduate studies in biology cum laude in 1970 at Bryn Mawr College in Pennsylvania.
In 1972, while still a graduate student in her mid-twenties at Johns Hopkins University, Pert discovered the opiate receptor, the molecular-docking site where drugs like opium and morphine bind to nerve cells in the human brain. This breakthrough finding led to the discovery of endorphins— natural, painkilling opiate-like chemicals in the brain, which Pert refers to as “the underlying mechanism for bliss and bonding.”
These findings dramatically increased our understanding of how drugs interact with the nervous system, and how the body and brain communicate with each other. Pert went on to discover numerous receptor sites for other drugs and naturally occurring substances in the brain, and she helped map the chemical communication system that operates between the brain and the immune system. This paved the way for an understanding of mind-body medicine and the biochemical basis for emotions.
In 1974, Pert received her Ph.D. in pharmacology, with distinction, from the Johns Hopkins University School of Medicine, where she worked in the laboratory of Solomon Snyder. From 1975 to 1987, Pert conducted research at the National Institute of Mental Health, where she served as Chief of the Section on Brain Biochemistry in the Clinical Neuroscience Branch. In 1987, Pert founded a private biotech laboratory that she directed for a few years, and then conducted AIDS research in the Department of Physiology and Biophysics at Georgetown University Medical Center in Washington D.C.
Pert spent over forty years trying to decode the biochemical language of what she refers to as the body’s “information molecules”— such as peptides and other ligands— which regulate the biochemical aspects of human physiology. Her interdisciplinary model of the “body-mind” explains how these chemicals distribute information simultaneously to every cell in the body. This understanding has unlocked the secret of how our emotions can literally create or destroy our health.
Many people believe that Pert should have won the Nobel Prize for her discovery of the opiate receptor— which is considered one of the most important discoveries in the history of neuroscience— but that internal politics interfered with her being properly recognized for her work. In this regard, it is important to note that Pert discovered the opiate receptor only after her supervisor had specifically ordered her to stop looking for it, concluding that it was a fruitless search, and Pert had to continue her research in secret.
Pert’s supervisor, Solomon Snyder, was later awarded the Lasker Award (an award for outstanding medical research) for its discovery without her. Such omissions are common in the world of science; contributions by graduate students in a research lab are rarely acknowledged beyond listing them as the primary author on the published article. However, Pert did something unusual: she protested, sending a letter to the head of the foundation that awards the prize, saying she had “played a key role in initiating the research and following it up” and was “angry and upset to be excluded.” Her letter caused significant discussion in the field, and many saw her exclusion as a typical example of the barriers women face in science careers.
In 1997, Pert’s book, Molecules of Emotion: Why You Feel the Way You Feel, was published. It recounts the story of her revolutionary discovery, the development of her research, and the evolution of her philosophy, as well as the storm of controversy that formed around her work. It reads like a spellbinding action-adventure story and offers a personal and insightful reinterpretation of neuroscience and mind-body medicine.
In 2001, Pert was featured in Washingtonian magazine as one of Washington’s fifty “Best and Brightest” individuals, and she was featured in Bill Moyers’s highly acclaimed PBS television series Healing and the Mind, as well as in the companion book that went with the series. Pert created the audio series Your Body Is Your Subconscious Mind, and also a psychoactive CD to enhance healing and personal transformation called To Feel Go(o)d.
Pert lectured extensively about the implications of her research for mind-body medicine, and her work helped to heal the pathological divisions in Western culture between mind and body, science and spirituality. “Finally, here is a Western scientist who has done the work to explain the unity of matter and spirit, body and soul!” wrote physician Deepak Chopra in the introduction to her book.
Pert’s research interests have ranged from decoding “information molecules” to trying to find cures for cancer and AIDS. She held a number of patents for modified peptides in the treatment of psoriasis, Alzheimer’s disease, chronic fatigue syndrome, stroke, and head trauma. One of these, peptide T, was found to be helpful for the treatment of AIDS. Pert has published more than 250 scientific papers on peptides and their receptors, and the role of these neuropeptides in the immune system. Some of Dr. Pert’s papers are among the most cited scientific papers in human history.
Pert died in 2013 at the age of 67. She is remembered for the important role that she played in how Mind-Body medicine became recognized as an area of legitimate scientific research. According to Pert’s website, her fans refer to her as The Mother of Psychoneuroimmunology and The Goddess of Neuroscience. A book about Pert’s life by Pamela Ryckman was recently published, Candace Pert: Genuis, Greed, and Madness in the World of Science.
I interviewed Candace Pert in 2004 for my book Conversations on the Edge of the Apocalypse. Candace generates a lot of warmth and positive energy. She gets excited and enthusiastic about her ideas, and she laughs a lot. My impression of Candace was that she was like an octopus, capable of doing innumerable tasks at once. Here are some excerpts from our conversation:
David: John Lilly was a big fan of your work. That’s how I first found out about you actually. He used to talk about you a lot.
Candace: I have pictures of him and me. He came to the National Cathedral. He was wonderful. God, that’s such a shame when people have to die. I’ve had people close to me die, and sometimes I think there are some amazing communications and synchronicities, where you think that they are trying to communicate, or some aspect of what has survived is coming back. There are some amazing stories, with things like doors slamming. I’ve had a few things happen at funerals. I’ve been through quite a few funerals in the last few years, and have seen things like leaves swirling at critical moments in the burial ceremony. There’s stuff that seems kind of amazing.
David: What is your concept of God, and do you see any teleology in evolution?
Candace: We don’t have to say that evolution is guided by intelligence, but it’s very clear to me that the process itself— stars cooling, entropy, evolution— is always leading toward more and more complexity and more and more perfection. So, the actual physical laws of the universe are God. You don’t have to invoke anything beyond that. I mean, God is not incompatible with the laws of science. God is a manifestation of that. There’s no incompatibility. We’re not talking about The Bible; we’re talking about the true laws of science. So, I guess that’s why I’m so into truth-seeking because truth-seeking is God-seeking at the same time.
David: What do you think happens to consciousness after death?
Candace: That’s a great question. Years ago, I had to answer that question to get a big honorarium, so I participated, and what I said then is still relevant. It’s this idea that information is never destroyed. More and more information is constantly being created, and it’s not lost, and energy and matter are interconvertible. So somehow there must be some survival because one human being represents a huge amount of information. So, I can imagine that there is survival, but I’m not sure exactly what form that it takes. I think Buddhist practice is interesting. There’s this whole idea that you’re actually preparing yourself for death, and if you do it just right you can make the transition better.
Carolyn and I have admired the work of inventor, architect, designer, philosopher, and futurist visionary Buckminster Fuller, who created numerous inventions and architectural designs. He is most well-known for his development of the geodesic dome, and for coining and popularizing the terms “synergetics” and “spaceship earth.”
Richard Buckminster “Bucky” Fuller was born in Milton, Massachusetts in 1895. His father was a successful businessman, and he was the grandnephew of journalist and women’s rights advocate Margaret Fuller. As a child, Fuller suffered from undiagnosed nearsightedness until the age of four, and he was teased by his elder sister Leslie for being “stupid.” Fuller spent much of his youth on Bear Island, off the coast of Maine, where he learned to sail and made tools and other items from materials he found in the woods. By the time he was twelve, he had invented a new system for propelling a rowboat.
Fuller attended the Milton Academy in Massachusetts, and in 1913 he was admitted to Harvard College, the undergraduate college of Harvard University. Fuller described himself as a “non-conforming misfit,” and he was expelled from Harvard twice— in 1914 for spending all his tuition money to court showgirls with a vaudeville troupe, and in 1915 for “irresponsibility and lack of interest.”
From 1917 to 1919 Fuller served in the Navy as a shipboard radio operator. In 1917 he married and had a daughter who died in 1922, just before her fourth birthday. Around this time, Fuller became president of a business that sought to provide affordable housing, and in 1927 he lost the job. Fuller became seriously depressed, drank heavily, and he took long walks by himself around Chicago. Fuller began contemplating suicide by drowning himself in Lake Michigan so that his family could benefit from his life insurance policy.
As he was contemplating suicide, Fuller had a profound, life-changing, mystical experience, that would provide direction and purpose for his life. Fuller felt as though he was suspended several feet above the ground and enclosed in a sphere of white light. A voice spoke directly to him and said: “From now on you need never await temporal attestation to your thought. You think the truth. You do not have the right to eliminate yourself. You do not belong to you. You belong to the Universe. Your significance will remain forever obscure to you, but you may assume that you are fulfilling your role if you apply yourself to converting your experiences to the highest advantage of others.”
Fuller said that this experience led to a profound re-examination of his life. He chose to embark on “an experiment, to find what a single individual could contribute to changing the world and benefiting all humanity.” In 1927 Fuller resolved to think independently, and to commit himself to “the search for the principles governing the universe, and help advance the evolution of humanity in accordance with them… finding ways of doing more with less, to the end that all people everywhere can have more and more.”
In 1933 Fuller designed a transportation vehicle called a Dymaxion car that was prominently featured in the 1934 Chicago World’s Fair. Dymaxion was a word that he coined that blended together the words “dynamic,” “maximum,” and “tension,” to sum up his goal of “maximum gain” and “advantage from minimal energy input.” The Dymaxion car’s aerodynamic bodywork was designed for increased fuel efficiency and top speed, and its platform featured a lightweight hinged chassis, rear-mounted V8 engine, front-wheel drive, and three wheels. There were limitations in its handling at high speeds, so it was never mass produced, although Walter Chrysler, Henry Ford, and other car manufacturers were interested in marketing the car.
During the mid-1940s, Fuller also invented the Dymaxion House, which was designed to be an inexpensive, energy-efficient, unusually strong, lightweight, home that had its own power source and was transportable. Fuller also designed a Dymaxion map of the world, which represents the surface of the world on an icosahedron (a polyhedron with 20 faces), which can be unfolded and flattened to two dimensions, and more accurately displays the size and shape of the oceans and continents than traditional flat maps or globes.
Between 1948 and 1949, Fuller taught at Black Mountain College in North Carolina. Although he was shy and withdrawn, Fuller was persuaded to participate in a theatrical performance produced by composer John Cage. During his rehearsals, Fuller broke through his inhibitions, and he became confident as a performer and speaker. It was here at Black Mountain College that Fuller began working on the project for which he is most famous, the development of geodesic domes.
A geodesic dome is a hemispherical structure based on a polyhedron composed of triangles. The triangular elements of the dome are structurally rigid, and they distribute the structural stress throughout the structure, making them unusually strong and able to withstand very heavy loads for their size. Many homes and other buildings have been built using this design, such as military radar stations, civic buildings, and exhibition attractions.
Fuller developed a novel system of mathematics known as “synergetics,” which is used to study systems in transformation, and emphasizes how whole systems generate behaviors that are unpredicted by the components of the system in isolation. Synergetics is interdisciplinary in nature, and it embraces a broad range of scientific and philosophical topics. Fuller’s two-volume work, Synergetics: Explorations in the Geometry of Thinking, which was published in 1975 and 1979, distills a lifetime of Fuller’s thinking on this complex subject.
Fuller also influenced language and coined many new terms. Fuller invented the words “livingry,” as opposed to “weaponry,” “world-around” instead of “worldwide,” and “sunsight” and “sunclipse,” instead of “sunrise” and “sunset.” He popularized the term “Spaceship Earth,” to promote a worldview that encourages everyone on Earth to act as a harmonious crew that is working toward a greater good. Fuller used the word “Universe” without the word “the” or “a” preceding it, and always capitalized the word, which our late friend Robert Anton Wilson incorporated into many of his books.
Fuller created many other inventions during his lifetime and is the author of more than thirty books. He was awarded 28 U.S. patents, and many of Fuller’s most famous architectural and design works were attempts to leverage technology in service of humanity. Some of his most popular books include Critical Path, Grunch of Giants, and Operating Manual for Spaceship Earth. In his book Critical Path he demonstrates how the resources on earth are plentiful enough for every human being to be living the lifestyle of a millionaire, if our resources were evenly distributed, and not wasted on weapons and war technology.
Fuller’s philosophy was embraced by the counterculture, and he was a hero to many in the alternative spiritual communities during the 1980s. I met Fuller twice during this time. In 1981 I asked Bucky to write something in my personal journal, that I had named Amazing Days. Bucky wrote, “To David, all days are amazing!”
Fuller died in 1983, shortly before his 88th birthday. During the period that led up to his death, his wife had been comatose in a Los Angeles hospital, dying of cancer. While visiting her he suddenly said excitedly, “She is squeezing my hand!” Fuller then stood up, had a heart attack, and died an hour later. Then his wife died thirty-six hours later. They are buried in Cambridge, Massachusetts.
In 1996 the Nobel prize in chemistry was awarded to the chemists who discovered a molecule that they called Buckminsterfullerene or Buckyball, after Fuller, due to its structural similarity to the geodesic domes that Fuller designed. In 2004, the U.S. Post Office released a commemorative stamp honoring Fuller on the 50th anniversary of his patent for the geodesic dome, which replicated the cover of the 1964 issue of Time magazine about Fuller’s work.
Some of the quotes that Buckminster Fuller is known for include:
Dare to be naïve.
I live on Earth at present, and I don’t know what I am. I know that I am not a category. I am not a thing— a noun. I seem to be a verb, an evolutionary process— an integral function of the universe.
We should do away with the absolutely specious notion that everybody has to earn a living. It is a fact today that one in ten thousand of us can make a technological breakthrough capable of supporting all the rest. The youth of today are absolutely right in recognizing this nonsense of earning a living. We keep inventing jobs because of this false idea that everybody has to be employed at some kind of drudgery because, according to Malthusian Darwinian theory he must justify his right to exist.
There is nothing in a caterpillar that tells you it’s going to be a butterfly.
When I am working on a problem, I never think about beauty… but when I have finished, if the solution is not beautiful, I know it is wrong.
Everything you’ve learned in school as “obvious” becomes less and less obvious as you begin to study the universe. For example, there are no solids in the universe. There’s not even a suggestion of a solid. There are no absolute continuums. There are no surfaces. There are no straight lines.
Everyone is born a genius, but the process of living de-geniuses them.
In order to change an existing paradigm, you do not struggle to try and change the problematic model. You create a new model and make the old one obsolete.
Mistakes are great, the more I make the smarter I get.
Carolyn and I met John Lilly in the late 1980s, and we become good friends over the years. He was an extraordinary human being and a gifted genius.
John C. Lilly, M.D. was a brilliant visionary researcher and maverick thinker, whose interdisciplinary work helped to revolutionize numerous scientific fields. He was a physician, neuroscientist, psychoanalyst, mind explorer, philosopher, writer, and inventor, who lived from 1915 to 2001 and made significant contributions to the fields of neurophysiology, biophysics, electronics, computer science, and neuroanatomy.
John pioneered radical new frontiers in psychology and neuroscience, and he charted his brave explorations of the human mind. However, John is perhaps best known as the man behind the fictional scientists dramatized in the Hollywood films Altered States and The Day of the Dolphin.
John was educated at CalTech, Dartmouth Medical School, and the University of Pennsylvania, and he did a large part of his scientific research at the National Institute of Mental Health during the 1950s. John pioneered early neuroscience research in electrical brain stimulation, mapping out the pleasure and pain pathways in the brain. He was the first person to conduct scientific studies attempting to communicate with dolphins and whales, which he recognized as having high intelligence, and he built his own dolphin-communication research lab in St. Thomas in the Virgin Islands. John also invented the isolation or flotation tank and did significant research in the area of sensory deprivation.
When I lived in LA during the early 1990s, I used to hang out regularly at John’s estate in Malibu, and after he moved to Hawaii, I spent a glorious month at his place in Maui. I loved John. I miss John’s brilliant mind, his clever jokes, and his unique perspective so much. John was eccentrically lovable, often unpredictable, and he had a great sense of humor. I interviewed John in 1991 for my book Mavericks of the Mind,” which also contains my interview with Carolyn. John was 76 at the time and I was 30.
Here are some excerpts from our conversation:
David: How did your work with the dolphins influence your experience in the isolation tank?
John: I discovered that dolphins have personalities and are valuable people. I began to wonder about whales, which have much larger brains, and I wondered what their capabilities are. There’s a threshold of brain size for language as we know it, and as far as I can make out it’s about 800 grams.
Anybody below that, like the chimpanzee or the gorilla can’t learn to speak a language. But above that language is acquired very rapidly, as in a baby. Well, this means that the dolphin’s life is probably as complicated as ours, but what about their spiritual life? Can they get out of their bodies and travel? Are they extraterrestrials? I asked those kinds of questions. Most people wouldn’t ask them. . . .
. . .when I started going out on the universe. . . in the tank, I’d come to a certain group of entities and I’d say, “Are you God?” And they’d say, “Well, we say that to some people but God is way up there somewhere with the angels.” And it turned out no matter how big they were, God is bigger. So finally I got to the Starmaker. But as Olaf Stapledon says in his book, it’s impossible to describe the Starmaker in human terms. . . .
I call God ECCO now. The Earth Coincidence Control Office. It’s much more satisfying to call it that. A lot of people accept this and they don’t know that they’re just talking about God. I finally found a God that was big enough. As the astronomer said to the Minister, “My God’s astronomical.” The Minister said, “How can you relate to something so big?” The astronomer said, “Well, that isn’t the problem, your God’s too small!”
[Note: Bottlenose dolphins have larger brains than humans— 1600 grams versus 1300 grams— and they have a brain-to-body-weight ratio that is greater than the great apes do (but lower than humans).]